2022 Home Opener Petco Park’s first game at home will be on Thursday, April 14, 2022. Find out more about the Padres’ first game. What Time Do The Padres Play Most SD Padres games start at 6:40 pm, while day games at Petco Park start at 1:10 pm. During the season, there are a lot … Continue reading Padres Schedule 2022 – Do The Padres Play Today?